A randomized control study of treating secondary stage II breast cancer-related lymphoedema with free lymph node transfer.
Identifieur interne : 001495 ( Main/Exploration ); précédent : 001494; suivant : 001496A randomized control study of treating secondary stage II breast cancer-related lymphoedema with free lymph node transfer.
Auteurs : Dimitrios Dionyssiou [Grèce] ; Efterpi Demiri [Grèce] ; Antonis Tsimponis [Grèce] ; Alexandros Sarafis [Grèce] ; Vasillios Mpalaris [Grèce] ; Georgia Tatsidou [Grèce] ; Georgios Arsos [Grèce]Source :
- Breast cancer research and treatment [ 1573-7217 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- methods : Combined Modality Therapy.
- pathology : Breast Cancer Lymphedema.
- therapy : Breast Cancer Lymphedema.
- Adult, Female, Humans, Microsurgery, Middle Aged, Physical Therapy Modalities, Surgical Flaps, Treatment Outcome.
Abstract
Microsurgical techniques are increasingly used for treating severe lymphoedema cases. The purpose of this study was to evaluate the effectiveness of free vascularized lymph node transfer (LNT) in stage II breast cancer-related lymphoedema patients in comparison with non-surgical management. During the last 3 years, 83 female patients were examined at our lymphoedema clinic. Finally, 36 cases were included in this study and randomly divided in two groups: group A patients (n = 18, mean age 47 years) underwent microsurgical LNT; followed by 6 months of physiotherapy and compression, while group B patients (n = 18, mean age 49 years) were managed by physiotherapy and compression alone for 6 months. Patients of both groups removed their elastic garments after 6 months and were re-examined 1 year later. All the 36 patients had detailed evaluation of the affected extremity including limb volume measurement, infection episodes and scale scoring of pain, feeling of heaviness and functional status both at baseline and 18 month. Limb volume reduction was observed in both groups; mean reduction was greater in group A (57 %) than in group B (18 %). Infection episodes in group A were significantly reduced compared to those in group B patients. All group A patients reported painless and feeling of heaviness-free extremities with overall functional improvement, while the corresponding changes in group B patients were no more than marginal. Moreover, the LNT procedure was estimated as cost effective compared to conservative treatment alone. LNT represents an effective therapeutic approach for stage II lymphoedema patients; it significantly reduces limb volume, decreases recurrent infections and improves the overall function.
DOI: 10.1007/s10549-016-3716-0
PubMed: 26895326
Affiliations:
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ddionyssiou@gmail.com.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Demiri, Efterpi" sort="Demiri, Efterpi" uniqKey="Demiri E" first="Efterpi" last="Demiri">Efterpi Demiri</name><affiliation wicri:level="1"><nlm:affiliation>Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Tsimponis, Antonis" sort="Tsimponis, Antonis" uniqKey="Tsimponis A" first="Antonis" last="Tsimponis">Antonis Tsimponis</name><affiliation wicri:level="1"><nlm:affiliation>Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:affiliation><country 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of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Tatsidou, Georgia" sort="Tatsidou, Georgia" uniqKey="Tatsidou G" first="Georgia" last="Tatsidou">Georgia Tatsidou</name><affiliation wicri:level="1"><nlm:affiliation>Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Arsos, Georgios" sort="Arsos, Georgios" uniqKey="Arsos G" first="Georgios" last="Arsos">Georgios Arsos</name><affiliation wicri:level="1"><nlm:affiliation>Aristotle University of Thessaloniki, Thessaloniki, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Aristotle University of Thessaloniki, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author></analytic><series><title level="j">Breast cancer research and treatment</title><idno type="eISSN">1573-7217</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Breast Cancer Lymphedema (pathology)</term><term>Breast Cancer Lymphedema (therapy)</term><term>Combined Modality Therapy (methods)</term><term>Female</term><term>Humans</term><term>Microsurgery</term><term>Middle Aged</term><term>Physical Therapy Modalities</term><term>Surgical Flaps</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique ()</term><term>Femelle</term><term>Humains</term><term>Lambeaux chirurgicaux</term><term>Lymphoedème après cancer du sein ()</term><term>Lymphoedème après cancer du sein (anatomopathologie)</term><term>Microchirurgie</term><term>Résultat thérapeutique</term><term>Techniques de physiothérapie</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème après cancer du sein</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Combined Modality Therapy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Cancer Lymphedema</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Breast Cancer Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Microsurgery</term><term>Middle Aged</term><term>Physical Therapy Modalities</term><term>Surgical Flaps</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association thérapeutique</term><term>Femelle</term><term>Humains</term><term>Lambeaux chirurgicaux</term><term>Lymphoedème après cancer du sein</term><term>Microchirurgie</term><term>Résultat thérapeutique</term><term>Techniques de physiothérapie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Microsurgical techniques are increasingly used for treating severe lymphoedema cases. The purpose of this study was to evaluate the effectiveness of free vascularized lymph node transfer (LNT) in stage II breast cancer-related lymphoedema patients in comparison with non-surgical management. During the last 3 years, 83 female patients were examined at our lymphoedema clinic. Finally, 36 cases were included in this study and randomly divided in two groups: group A patients (n = 18, mean age 47 years) underwent microsurgical LNT; followed by 6 months of physiotherapy and compression, while group B patients (n = 18, mean age 49 years) were managed by physiotherapy and compression alone for 6 months. Patients of both groups removed their elastic garments after 6 months and were re-examined 1 year later. All the 36 patients had detailed evaluation of the affected extremity including limb volume measurement, infection episodes and scale scoring of pain, feeling of heaviness and functional status both at baseline and 18 month. Limb volume reduction was observed in both groups; mean reduction was greater in group A (57 %) than in group B (18 %). Infection episodes in group A were significantly reduced compared to those in group B patients. All group A patients reported painless and feeling of heaviness-free extremities with overall functional improvement, while the corresponding changes in group B patients were no more than marginal. Moreover, the LNT procedure was estimated as cost effective compared to conservative treatment alone. LNT represents an effective therapeutic approach for stage II lymphoedema patients; it significantly reduces limb volume, decreases recurrent infections and improves the overall function.</div></front></TEI><affiliations><list><country><li>Grèce</li></country></list><tree><country name="Grèce"><noRegion><name sortKey="Dionyssiou, Dimitrios" sort="Dionyssiou, Dimitrios" uniqKey="Dionyssiou D" first="Dimitrios" last="Dionyssiou">Dimitrios Dionyssiou</name></noRegion><name sortKey="Arsos, Georgios" sort="Arsos, Georgios" uniqKey="Arsos G" first="Georgios" last="Arsos">Georgios Arsos</name><name sortKey="Demiri, Efterpi" sort="Demiri, Efterpi" uniqKey="Demiri E" first="Efterpi" last="Demiri">Efterpi Demiri</name><name sortKey="Mpalaris, Vasillios" sort="Mpalaris, Vasillios" uniqKey="Mpalaris V" first="Vasillios" last="Mpalaris">Vasillios Mpalaris</name><name sortKey="Sarafis, Alexandros" sort="Sarafis, Alexandros" uniqKey="Sarafis A" first="Alexandros" last="Sarafis">Alexandros Sarafis</name><name sortKey="Tatsidou, Georgia" sort="Tatsidou, Georgia" uniqKey="Tatsidou G" first="Georgia" last="Tatsidou">Georgia Tatsidou</name><name sortKey="Tsimponis, Antonis" sort="Tsimponis, Antonis" uniqKey="Tsimponis A" first="Antonis" last="Tsimponis">Antonis Tsimponis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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